8/5/2023 0 Comments Thebrain and heart![]() Possible reasons include impaired blood supply to the brain and dysfunction of the hippocampus, which is the memory’s control center,” explained André Fischer, research group leader at the DZNE’s Göttingen site and professor at the Department of Psychiatry and Psychotherapy at UMG. “People with cardiological problems and heart failure in particular may experience noticeable cognitive deficits and increased risk of developing Alzheimer’s disease. Moreover, affected individuals have an increased risk of developing dementia. Physical fitness and quality of life suffer as a result. In Germany, about four million people are affected by what is called “heart failure”: Their heart muscle is too weak to pump enough blood through the body and is therefore abnormally enlarged. The study data are published in the scientific journal “ EMBO Molecular Medicine”. The involved experts see these results as potential approaches for therapies. In mice, a specific drug which is known to affect gene activity alleviated the mental deficits. They consider that they have found a possible cause for the increased risk of dementia in people with heart problems. ![]() Researchers at the German Center for Neurodegenerative Diseases (DZNE), the University Medical Center Göttingen (UMG) and the German Center for Cardiovascular Research (DZHK) come to this conclusion based on laboratory studies. Heart problems cause disturbed gene activity in the brain’s memory center, from which cognitive deficits arise. Evidence of Disturbed Gene Activity in the Brain as a Result of Heart Problems
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